HBTU – CAS# 94790-37-1

HBTU is commonly employed as a coupling agent in peptide synthesis, facilitating the formation of peptide bonds between amino acids. It reacts with amino acids and peptide fragments to activate carboxyl groups, enabling efficient and high-yielding peptide bond formation.

One of the significant advantages of HBTU is its ability to produce peptide products with minimal epimerization or racemization. This characteristic makes it particularly valuable in the synthesis of peptides for pharmaceutical research and drug development, where maintaining the correct stereochemistry is crucial.

Furthermore, HBTU exhibits excellent solubility in organic solvents, allowing for easy handling and dissolution in reaction mixtures. Its compatibility with various protecting groups and amino acid derivatives adds to its versatility in peptide synthesis.

In addition to peptide synthesis, HBTU finds application in other organic transformations, such as amidations and esterifications. Its ability to activate carboxylic acids and esters enhances the efficiency and selectivity of these reactions.

However, it is important handle it with caution as it can cause skin and eye irritation. Personal protective equipment, such as gloves and goggles, should be worn when working with HBTU to minimize the risk of exposure. Proper ventilation in the working area is also recommended to prevent the buildup of vapors.

In conclusion, HBTU (CAS 94790-37-1) is a versatile coupling reagent widely used in peptide synthesis and organic chemistry. Its ability to activate carboxylic groups and promote peptide bond formation makes it a valuable tool in the production of peptides for pharmaceutical research. With proper handling and safety measures, HBTU offers efficient and reliable results in various organic transformations.